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Kohat University of Science and Technology (KUST) enjoys an enviable status as a seat of learning amongst the top-notch universities of the country, owing to its rich cultural heritage and its quality education and research that are being provided to a multitude of students at affordable cost. It is a matter of immense pleasure for me that KUST is striving for academic excellence and upholding the highest standards of higher education and in imparting education; it has  made significant improvement and Read more...

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Welcome to Kohat University of Science & Technology (KUST)! We thank you for visiting us in person or through our site. 
Kohat University of Science and Technology (KUST) is one of the most important seat of higher learning in the south region of Khyber Pakhtunkhwa (KPK) province. Since its inception, KUST is making tremendous contribution to the education system of Kohat and surrounding districts. The University strives to achieve academic excellence through continuous improvement of Read more...

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Dr. Zia ur Rehman

Dr. Zia ur Rehman


 

 Zia ur Rehman, PhD, Postdoc

 

Personal

Email

 

ziamarwat77@gmail.com

z.rehman@kust.edu.pk

Lab Page

Permanent Address

http://zialab.strikingly.com/

District Lakki Marwat, Village and P/O Mela Mandra Khel, Khyber Pakhtunkhwa, Pakistan

Mailing Address Present

Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology, Kohat, 26000, KPK, Pakistan

Employment Status

Associate Professor

Phone

+92-345-9856056 (WhatsApp)

+92-333-7757596

Academics

PhD          (2012) University Medical Center Groningen, University of Groningen, The Netherlands.

Thesis title: “Nanocarrier-cell interaction: exploring the cell surface &       intracellular trafficking”

Advisor: Prof. Dr. Dick Hoekstra

MPhil       (2008) (Molecular Biology/Biochemistry) Quaid-i-Azam University Islamabad, Pakistan.

                        Thesis title: Mapping Non-Syndromic Hearing Impairment Genes

                        Advisor: Prof. Dr. Wasim Ahmad

MSc           (2006) (Molecular Biology/Biochemistry), Quaid-i-Azam University Islamabad, Pakistan.

BSc            (2003) (Biology, Chemistry), Government Degree College, Lakki Marwat, Pakistan.

Current Position

            Postdoctoral Fellow (April 4, 2018 to November, 2019)

Department of Medical Biochemistry and Biophysics, Umeå University Sweden

Assistant Professor

            Department of Biotechnology and Genetic Engineering, Kohat, Pakistan

 Courses taught: Cell Biology, Molecular Biology, Cell Signaling, Fundamental of Genetics, Gene Therapy, Molecular Medicine and Drug development, Nanobiotechnology, Biochemistry

 Previous Position

 Lecturer (2007-2014)

Department of Biotechnology and Genetic Engineering, Kohat, Pakistan

Awards/Honors

 COMSTECH, Best Paper Award (among all OIC member countries). Awarded in 15th COMSTECH General Assembly Meeting, 31 May- 01June, 2016

  • Postdoctoral Fellowship from Department of Biochemistry and Biophysics, Umeå University, Sweden (April 2018-onward)

Publications

  1. Zia ur Rehman, Dick Hoekstra, Inge S. Zuhorn Kinases in cationic lipid/polymer-mediated gene delivery. Drug Discovery Today Volume 15, Issues 23–24, December 2010, Page 1110. (Impact factor: 7.851)
  2. ur Rehman Z, Hoekstra D, Zuhorn IS. “Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection”. J Control Release. 2011 Nov 30; 156(1):76-84. doi: 10.1016/j.jconrel.2011.07.015. Epub 2011 Jul 20. (Impact factor: 9.776).
  3. ur Rehman Z, Sjollema KA, Kuipers J, Hoekstra D, Zuhorn IS. “Nonviral gene delivery vectors use syndecan-dependent transport mechanisms in filopodia to reach the cell surface”. ACS Nano. 2012 Aug 28;6 (8):7521-32. doi: 10.1021/nn3028562. Epub 2012 Aug 8. (Impact factor: 15.881)
  4. Rehman ZU, Zuhorn IS, Hoekstra D. “How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances”. J Control Release. 2013 Feb 28; 166(1):46-56. doi: 10.1016/j.jconrel.2012.12.014. Epub 2012 Dec 20. (Impact factor: 9.776).
  5. Noor Muhammad, Waheed Ullah, Zia ur Rehman. “Applications of bacterial outer membrane protein FhuA variants functionalized nanocompartments”. Journal of Rashid Latif Medical College. 1 (2012) 40-43.
  6. ur Rehman Z, Hoekstra D, Zuhorn IS. “Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis.” ACS Nano. 2013 May 28;7(5):3767-77. doi: 10.1021/nn3049494. Epub 2013 Apr 24. (Impact factor: 15.881)
  7. Zia ur Rehman, Waheed Ullah, Noor Muhammad. “Cationic nanocarriers mediated gene transfer, recent advances showing where they lag behind their viral counterparts”. Journal of Rashid Latif Medical College. 2 (2013) 32-35.
  8. Farooqi AA, Rehman ZU, Muntane J. “Antisense therapeutics in oncology: current status”. Onco Targets Ther. 2014 Nov 3;7: 2035-42. (Impact factor: 4.146)
  9. Azizullah A, Rehman ZU, Ali I, Murad W, Muhammad N, Ullah W, Häder DP. Chlorophyll derivatives can be an efficient weapon in the fight against dengue. Parasitol Res. 2014 Dec;113(12):4321-6. (Impact factor: 2.29)
  10. Khan SA, Muhammad N, Khan, Kamal A, Rehman ZU, Khan S. Genetics of Human Bardet-Biedl Syndrome, an Updates. Clin Genet. 2016 Jan 14. (Impact factor: 4.44)
  11. Khan M, Daud MK, Basharat A, Khan MJ, Azizullah A, Muhammad N, Muhammad N, Ur Rehman Z, Zhu SJ. Alleviation of lead-induced physiological, metabolic, and ultramorphological changes in leaves of upland cotton through glutathione. Environ Sci Pollut Res Int. 2016 Jan 19. (Impact factor: 4.223)
  12. Shakir SK, Kanwal M, Murad W, Zia Ur Rehman, Shafiq Ur Rehman, Daud MK, Azizullah A. Effect of some commonly used pesticides on seed germination, biomass production and photosynthetic pigments in tomato (Lycopersicon esculentum). Ecotoxicology. 2016 Mar;25(2):329-41. (Impact factor: 2.823)
  13. Deeba F, Raza I, Muhammad N, Rahman H, Ur Rehman Z, Azizullah A, Khattak B, Ullah F, Daud MK. Chlorpyrifos and lambda cyhalothrin-induced oxidative stress in human erythrocytes: In vitro studies. Toxicol Ind Health. 2016 Apr 21. (Impact factor: 2.068)
  14.  Uzma S, Azizullah A, Bibi R, Nabeela F, Muhammad U, Ali I, Rehman ZU, Häder DP. Effects of industrial wastewater on growth and biomass production in commonly grown vegetables. Environ Monit Assess. 2016 Jun;188(6):328. (Impact factor: 2.51)
  15. Ullah W, Qasim M, Rahman H, Bari F, Khan S, Rehman ZU, Khan Z, Dworeck T, Muhammad N. Multi drug resistant Pseudomonas aeruginosa: Pathogen burden and associated antibiogram in a tertiary care hospital of Pakistan. Microb Pathog. 2016 Aug;97:209-12. (Impact factor: 3.738)
  16. Ullah W, Qasim M, Rahman H, Khan S, Rehman ZU, Ali N, Muhammad N. CTX-M-15 and OXA-10 beta lactamases in multi-drug resistant Pseudomonas aeruginosa: First report from Pakistan. Microb Pathog. 2017 Apr;105:240-244.  (Impact factor: 3.738)
  17. Tahira S, Khan S, Samrana S, Shahi L, Ali I, Murad W, Rehman ZU, Azizullah A.  Bio-assessment and remediation of arsenic (arsenite As-III) in water by Euglena gracilis. J Appl Phycol (2018). https://doi.org/10.1007/s10811-018-1593-0. (Impact factor: 3.215)
  18. Qaisar F, Habib A, Muhammad N, Rehman Z. Non-Viral Vectors for Cystic Fibrosis Therapy: Recent Advances. J Genet Disor Genet Rep (2018)  7:3. doi: 10.4172/2327-5790.1000179
  19. Faisal Qaisar; Anum Habib; Maira Riaz; Zia Ur Rehman.  Barriers and recent advances in non-viral vectors targeting the lungs for cystic fibrosis gene therapy. Nanomedicine Journal (2019) Volume 6, Issue 2, Spring 2019, Page 75-84.
  20. Isabelle M.S. Degors, Cuifeng Wang, Zia ur Rehman, Inge S. Zuhorn. Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors. Acc. Chem. Res. 2019, 52, 7, 1750–1760 (Impact factor: 22.384)
  21. Faryal Saad, Zia Ur Rahman, Aamir Khan, Rabia Noushin, Irfan Ullah, Farman Ullah Dawar, Shahid Naiz Khan, Rafiqe Hussain, Kenza Javed, Abid ur Rehman, Amna Fayaz, Zohra Saifullah and Kalim Ullah. Detection of Cytomegalovirus in Pregnant Women of Lakki Marwat and Bannu, Khyber Pakhtunkhwa, Pakistan. Pakistan J. Zool., Vol. 53, Iss. 1, pp 363-366. (Impact factor: 0.83).
  22. Aftab Nadeem; Athar Alam; Eric Toh; Si Lhyam Myint; Zia Ur Rehman; Tao Liu; Marta Bally; Anna Arnqvist; Hui Wang; Jun Zhu; Karina Persson; Bernt Eric Uhlin; Sun Nyunt Wai. Phosphatidic acid-mediated binding and mammalian cell internalization of the Vibrio cholerae cytotoxin MakA. (2021). PLoS Pathog 17(3): e1009414. https://doi.org/10.1371/journal.ppat.1009414. (Impact factor: 6.823).
  23. Nazneen Akhtar, Sehresh Khan, Shafiq Ur Rehman, Zia Ur Rehman, Amana Khatoon, Eui Shik Rha, and Muhammad Jamil.  Synergistic Effects of Zinc Oxide Nanoparticles and Bacteria Reduce Heavy Metals Toxicity in Rice (Oryza sativa L.) Plant. Toxics 2021, 9(5), 113; https://doi.org/10.3390/toxics9050113. (Impact factor: 4.146).
  24. Nazneen Akhtar, Sehresh Khan, Shafiq Ur Rehman, Zia Ur Rehman, Zia Ur Rehman Mashwani, Eui Shik Rha,and Muhammad Jamil. Zinc Oxide Nanoparticles Enhance the Tolerance and Remediation Potential of Bacillus spp. against Heavy Metal Stress. Adsorption Science & Technology. Volume 2021 |Article ID 1774528 | https://doi.org/10.1155/2021/1774528 (Impact factor: 4.232).
  25. Sher A. Khan, Saadullah Khan, Noor Muhammad, Zia Ur Rehman, Muhammad A. Khan, Abdul Nasir, Anwar Kamal Khan, Hassan Khan, Umm-e- Kalsoom and Naveed Wasif. The first report of a pathogenic variant in RFX2 causing non-syndromic tooth agenesis in a consanguineous Pakistani family. Genet., 25 January 2022 https://doi.org/10.3389/fgene.2021.782653. (Impact factor: 4.6).
  26. Neelam Meraj, Muhammad Yasin, Zia Ur Rehman, Haleema Tahir, Humaira Jadoon, Niamat Khan, Rabia Shahid, Maria Zubair, Irba Zulfiqar, Musarrat Jabeen, Shahzadi Neelam, Abdul Hameed, Shamim Saleha. Fragile X premutation carrier screening in Pakistani preconception women in primary care consultation. BMC Womens Health. 2022 Mar 4;22(1):57. DOI: 10.1186/s12905-022-01632-1. (Impact factor: 2.809).
  27. Nazneen Akhtar, Sehresh Khan, Muhammad Jamil, Shafiq Ur Rehman, Zia Ur Rehman and Eui Shik Rha. Combine Effect of ZnO NPs and Bacteria on Protein and Gene’s Expression Profile of Rice (Oryza sativa L.) Plant. Toxics 2022, 10(6), 305; https://doi.org/10.3390/toxics10060305 (Impact factor: 4.146).
  28. Rabia Shahid, Muhammad Yasin, Zia Ur Rehman, Humaira Jadoon, Haleema Tahir, Neelam Meraj, Niamat Khan, Maria Zubair, Irba Zulfiqar, Maha Nowshid, Arfa Azeem, Musarrat Jabeen, Abdul Hameed & Shamim Saleha. Maternal FMR1 alleles expansion in newborns during transmission: a prospective cohort study. Pediatr Res (2022). https://doi.org/10.1038/s41390-022-02128-2 (Impact factor:).

Research Abstracts published in Conference books/proceedings

  1. Zia ur Rehman, Dick Hoekstra, Inge S. Zuhorn Kinases in cationic lipid/polymer-mediated gene delivery. Drug Discovery Today Volume 15, Issues 23–24, December 2010, Page 1110. (Impact factor: 7.851)
  2. Bibi S, Azizullah A, Akhtar R, Murad W, Rehman ZU, Daud MK (2016) “ Phytotoxicity evaluation of atrazine to host crops using the morphological, physiological and biochemical characteristics of Zea mays as endpoints” 6th International Conference of Environmentally Sustainable Development, COMSATS Institute of Information Technology Abbottabad, Pakistan.
  3. Muhammad U, Khattak TN, Rehman ZU, Murad W, Azizullah A (2016) “ Biopesticidal activities of Neem seeds and Turmeric rhizome extracts against Okra Pests” 6th International Conference of Environmentally Sustainable Development, COMSATS Institute of Information Technology Abbottabad, Pakistan.
  4. Tahira S, Zahir S, Daud MK, Murad W, Rehman ZU, Muhammad N, Azizullah A (2016) “Ecotoxicological evaluation of arsenic using biochemical parameters of Euglena gracilis as endpoints” 6th International Conference of Environmentally Sustainable Development, COMSATS Institute of Information Technology Abbottabad, Pakistan.
  5. Faisal Qaisar, Anum Habib and Zia ur Rehman. Nonviral vectors for Gene therapy of cystic fibrosis and related monogenic diseases: Limitations and recent advances. Abstract book “Recent Advances in Biotechnology” April 26-27, 2017. Page 52.
  6.  Zia ur Rehman, Noor Muhammad Exploring the Cell surface and intracellular trafficking of nanocarriers for Gene therapy. Abstract book “Recent Advances in Biotechnology” April 26-27, 2017. Page 20.
  7. Faisal Qaisar, Anum Habib Zia ur Rehman, Durre-e-Nayab and Aamina Azeem. Abstract Book “1st National Conference on Recent innovation in Medicinal Chemistry and Biochemistry”. February 20-22, 2018.

Selected Conferences and Presentations

  1. Papers presented in Seminars/Conferences/Symposia
  • “Umeå Cell Biology Symposium” (May 30-31, 2018). Chemical Biology Center (KBC), Umeå University, Sweden.
  • “03 Days National Workshop on NANOMEDICINE Advancements and Challenges in Pakistan” (November 27-29, 2017). Department of Pharmacy, Quaid-e-Azam University Islamabad.
  • Nanomedicine: Novel Approaches in Drug Delivery” (11-12 April, 2017). Department of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan.
  • “Two-Day National Conference on Recent Advances in Biotechnology” (26-27 April, 2017). Department of Biotechnology and Genetic Engineering, KUST, Kohat.
  • “Four Day Training Workshop on Capacity Building of Biotechnologists” (June 08-11, 2015). Department of Biotechnology and GE, KUST, Kohat.
  • Nanobiotechnological approaches for Gene Therapy (16-04-2013). Department of Biotechnology and Genetic Engineering, Kohat, Pakistan.
  • Nanocarrier cell interactions: Exploring cell surface and intracellular trafficking (01-04-2013). Dunnicliff Chemical Society, Department of Chemistry, GC University, Lahore, Pakistan.
  • Nanocarriers as modern drug delivery vehicles (28-02-2013). Institute of Chemical Sciences, University of Peshawar, Pakistan.
  • Liposome Conference (25-09-2012). Ameland, the Netherlands.
  1. Seminars/Conferences/Symposia (Attended/Posters Presented)
  • Basic Course in SEM and TEM. (October 02-04, 2018). Umeå Core Facility Electron Microscopy (UCEM). Umeå University, Sweden
  • Dynamic Endosomes (24-29 September, 2011). Crete, Chania, Greece.
  • Cellular Delivery of Therapeutic Macromolecules (26-29 June, 2010). Cardiff University, United Kingdom.
  • Liposome Conference (2009). Ameland, the Netherlands.

Projects

  1. Completed
  1. Interaction of nanocarriers for gene delivery with cells (PhD Thesis)
  2. Nanocarriers for gene delivery and their intracellular escape from endosomes (PhD Thesis)
  3. Role of various kinases affecting the overall efficiency of cationic nanocarriers (PhD Thesis)
  4. Identification of Genes involved in Human hereditary disorders (PKR: 0,5Millions) Higher Education Commission, Pakistan (as Co-PI)
  1. Projects in Progress
  • Fragile X genetic Testing for identification of FMR1 permation female carrier in potential population (PKR: 478 Millions Funded by HEC, Pakistan). (as Co-PI)
  • Nanocarrier for Gene Delivery: Enhancing the transfer of CFTR gene into Humans Normal and CFTR- Cells using Cost Effective Cationic Nanocarriers (PKR: 595Millions Funded by HEC, Pakistan) (as Principal Investigator)
  • Non-viral Vectors for Gene Delivery: Enhancing the transfection Efficiency of Cost Effective Nano-Carriers for Potential Clinical and Industrial Applications (PKR: 423Millions Funded by HEC, Pakistan) (as Principal Investigator)

 

Students Supervision

  1. PhD
    • Enrolled         03
  2. MPhil/Ms
    • Completed      08                    Enrolled         05
  3. BS (4 Years Program)
    • Completed      06                    Enrolled         03                               

 References

  • Dr. Anna Arnqvist - Associate Professor

anna.arnqvist@umu.se

Umeå University Medical Biochemistry and Biophysics SE-901 87 Umeå, SWEDEN

Visiting Address

KBC-building, 6th floor

Tel:  +46 90 786 6539

  • Dr. Inge S. Zuhorn

i.zuhorn@umcg.nl

University Medical Center Groningen, University of Groningen,

Department of Cell Biology, A. Deusinglaan 2, 9713 AV Groningen, the Netherlands.

Phone +31-50-3638168

Prof. Dr. Wasim Ahmad

wahmad@qau.edu.pk

Professor

Chairman Department of Biochemistry

Faculty of Biological Sciences

Quaid-I-Azam University, Islamabad, Pakistan

Phone: +92-051-9064-3003                            

 

                           


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